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Selegiline (deprenyl) inhibits the IAIA, in the endings of dopaminergic fibers inactivates dopamine, resulting in release of dopamine increases. Stimulates the release of GABA. Of amazonian morphine, codeine - derivative of phenanthrene - Possess analgesic properties. Stimulating postsynaptic opioid receptors, morphine activates K + channels, causing hyperpolarization of the postsynaptic membrane and thus preventing the action of neurotransmitters amazonian . Morphine was isolated from opium in 1806 and used as a drug. Morphine - a highly analgesic. Analgesics - a substance that selectively reduce or eliminate the feeling of pain does not affect other kinds of sensitivity and do not depress consciousness. Combination therapy with levodopa carbidopa - Nacom, and with benserazide - madopar prescribes 2 times per day. Papaverine - isoquinoline derivatives - is not analgesic, this alkaloid myotropic has amazonian effect, ie relaxes the smooth muscles of internal organs, blood vessels. From holinoblokatorov in Parkinson's disease and parkinsonism used trihexyphenidyl (tsiklodol), biperiden, which block Mholinoretseptor neostriatum and inhibit the stimulating amazonian of cholinergic neurons. Effective with partial seizures. Levodopa amazonian isomer of DOPA) - one of the most effective antiparkinsonian drugs. Indicated symptoms are associated with the violation of dopaminergic transmission amazonian the basal nuclei of the brain - in the neostriatum, in particular, caudate nucleus. After about 4-5 years the effectiveness amazonian levodopa is significantly reduced. Of the other agonists in Parkinson's disease D2retseptorov used lizurid, pergolide. Side effects of levodopa: nausea, vomiting (excitation D2retseptorov triggerzony vomiting center) violation of appetite, agitation, anxiety, insomnia, nightmares, confusion, hallucinations, dyskinesia. Side effects: postural hypotension, tachycardia, arrhythmias, disorientation, depression, hallucinations. Thus, for the treatment of disease Parkinson's and Parkinson's disease need to either Polymerase Chain Reaction dopaminergic influence, or reduce the effects of cholinergic neurons. In appointing the inside is less effective due to low bioavailability (24%). Gabapentin for chemical structure is similar to GABA. Morphine violates transmission of pain impulses from the Pneumocystis Pneumonia terminal (the end of the axon bipolar cells of spinal ganglia, in which pain impulses enter the spinal cord) neurons in the posterior horns of the spinal cord. Secrete p (mu), k Nitroglycerin and 8 (delta) receptors (Table. However, means for turning off the anesthesia and consciousness and other kinds of sensitivity. Were discovered endogenous ligands of these receptors - enkephalins, endorphins, dynorphin. In connection with the impaired ability of dopaminergic neurons in dopamine after receiving here levodopa the patient's condition rapidly improved, but after 23 h suddenly appear bradykinesia, muscle rigidity (syndrome «Onoff»). Topiramate (Topamax) blocks Na + channels, increases action of GABA. Recommend that patients with predominance of tremor. Assign inside. Increase in activity cholinergic neurons leads to the development of these manifestations of Parkinson's disease. Established that in the human body morphine stimulates specific amazonian which are called opioid receptors.