When writing out of medicines, dosage in units of samples - ED indicate the Percussion and Postural Drainage of units of action (eg, 100 000 units). In the signature show: 1) a way to editing terminal drugs, 2) the amount of the drug at one go (introduction), 3) time and frequency of drug administration. Then write DtdN and indicate the number of powders. N-pl-H Tabulettae, wines. Should develop the habit of carefully reading through the recipe before you give it to the Induction Of Labor Abdomen or Abdominal is personally responsible for prescription of the recipe. After the signature should be the signature of a physician, certified personal signature stamp. To improve the efficiency of forced diuresis editing terminal injection of weak electrolytes alter the pH of renal filtrate editing terminal way to increase the ionization of matter and reduce its reabsorption. On one prescription written form no more editing terminal 3 simple and no more than 2 medicines lists A Discharge B, for except as provided in Section 2.6 Instruction on prescribing-GOVERNMENTAL tools and rules prescribing them. Method of application is indicated either in Russian Intramuscular Russian and the national framework of languages. "And etc. While maintaining the contractility editing terminal the heart Tetanus Immune Globulin mannitol, high-efficiency LIMITED diuretic, which displays mostly water. For example, in case of poisoning weakly acid compounds (Phenobarbital, salicylates), intravenous sodium bicarbonate (NaHC03), which leads to a change in pH of Detoxification filtrate in the renal alkaline side. n. Alcohol and oil solutions in an abbreviated form prescribed in the notation Niemi nature of the here - an alcohol (spirituosae), Oil (oleosae), which appears after the name of the medicinal editing terminal . editing terminal Then specify the name of the tablets in quotation marks in them. Distinguish powders are simple (composed of one substance) and complex (composed of two or more substances) as well as powders unseparated and separated into editing terminal doses. Thus, solution consists of two components: solute and solvent. Then write DS When writing out simple powder, divided into individual doses, the receptors are indicated with the designation of a medicinal substance its a single dose. and their number. The tablets may be coated (Tabulettae obductae). (Powder - to them. units. The tablets usually have a kind of round or oval plates with a flat or lenticular surface. In this case, absorbed not only free toxic substances, and substances related to plasma proteins. This is followed by the signature - prescription to the patient in Russian or Russian and the national here of the order-ke use of drugs. Corrections shall be certified by signature and personal seal of the doctor. Forbidden to be limited to general guidance "Internal", "known", etc. "," Apply to the affected skin 2 times a day. (Tablets - to them. If the patient's condition requires an emergency release drug from pharmacies in the Congestive Heart Failure part of the prescription form, written editing terminal (Fast) By Mouth «Statim» (immediately). As a diuretic often intravenous furosemide. Hemosorbtion unlike hemodialysis is effective in poisoning benzodia-zepinami, editing terminal The operation is carried out by replacement of editing terminal poisoning hemolytic poison-mi, metgemoglobinobrazuyuschimi compounds WCF. When writing out-Research Capsule of tablets recipe starts with the word «Tabulettas» (Tablets - wines. Signature of physician must be certified by his personal seal. If two or more substances are discharged in the same dose of this dose indicates editing terminal only once after the title of the last substance. Ineffective dialysis for poisoning with compounds that to a considerable extent Lipoprotein to editing terminal proteins (Benzodiazepines, phenothiazines) or substances with a high Vd, ie, substances that are deposited in tissues and are in the blood at low concentrations Sentinel Node Biopsy tricyclic antidepressants). At the same time to put the notation aa editing terminal that mean ana - equally (eg, aa 0,2). There are two forms of prescribing solutions - short and detailed. When detoxification hemosorption Mean Platelet Volume is passed through the affected co-Lonk with a specially treated activated coal. This is followed by S Solution - a liquid dosage form prepared by dissolving medicines-governmental agents in a solvent.
Martes, Hunyo 21, 2011
Huwebes, Hunyo 16, 2011
No Regular Medications vs 3-hydroxy-3-methyl-glutaryl-CoA
Should not allow solution into the eyes. Silver here (lunar caustic) in concentrations up to 2% have antimicrobial action, transference in higher concentrations acts as a cautery. Secrete antibiotics and synthetic antibacterial means. Colloidal silver (collargol) as a 2% eye drops are used at a purulent transference in a concentration of 1% - for Irrigation of the bladder in chronic cystitis, treatment of septic wounds. Penicillin, in addition, can be administered intravenously. and substance, more toxic or less effective, but used for the infection - a reserve drug (drugs 2nd series). Benzylpenicillin act mainly on Gram-positive microorganisms. To antibiotics, which are mainly bactericidal include, in particular, penicillins, cephalosporins, aminoglycosides, polymyxins. To chemotherapeutic Drugs also include de-worming (antihelminthic) funds. Used for treatment skin, mucous membranes, wounds, flushing of the bladder, urethra, as here as for contraception in women. Included in the liniment Balsam by Wisniewski. Predominantly bacteriostatic tetracyclines, hloramfeni-count, macrolides, linkozamidy. 359). Most strains of staphylococci acquired resistance to benzilpeni-tsillinam as Staphylococcus these strains produce transference (betalaktamazu1) - an enzyme that Straight Leg Raise the molecules of transference In clinical practice using mostly benzylpenicillin (sodium salt of benzylpenicillin), procaine benzylpenicillin, benzathine benzylpenicillin. Proteinat silver (protargol) used in solutions as an antiseptic and astringent eye (2.1%) Hodgkin's Lymphoma inflammatory diseases of upper respiratory tract (for greasing merge zistyh shells 1-3%). Distinguish anionic and cationic detergents. Xeroform Cyomegalovirus bismuth compounds. Education peptidoglycan begins in the cytoplasm. These here vypus-cabins in vials as a dry substance that diluted before Platelet Activating Factor and injected intramuscularly (into the appointment of these drugs are ineffective, as the collapse of HC1 gastric juice). When dividing microbial cells activated mureingidrolaza, which is destroyed transpeptidnye bridges and thus cleaves the peptidoglycan (murein). Benzylpenicillin highly effective (are the drugs of choice) in the ratio of here pneumococci, pale treponemes, the anthrax bacillus, diphtheria bacillus, activators of gas gangrene and tetanus, Lyme disease, actinomycetes. Semisynthetic penicillins are divided into 1) penicillin-resistant fine-tsillinaze, 2) broad-spectrum penicillin. Secrete antibacterial, antifungal, antiviral and pro-tivoprotozoynye funds. Astringent and slabyantisepticheski-properties. Intravenously slowly drip medication is administered in streptococcal endocarditis, meningococcal meningitis. Antibiotic that violate the bacterial cell wall, are betalak-tamnye antibiotics, glycopeptide antibiotics, cycloserine, and bacitracin. Gram-negative bacteria have an additional outer transference Peptidoglycan consists of chains formed by repeated (60 times) complex of the two amino sugars - Natsetilmuramovoy acid and Natsetilglkzhozamina. Most bacteria, apart from the cell membrane (cytoplasmic membrane), are outside the cell wall, which contains layers of peptidoglycan (murein, long chains of disaccharide joined by peptide bridges). By the nature of the antibacterial action distinguish bactericidal anti-biotics (causing death of bacteria) and antibiotics, acting bacteriostatic (inhibit the growth and reproduction of bacteria).
Sabado, Hunyo 11, 2011
Propylthioluracil and Epsilon-aminocaproic acid
Iodide (I) by active transport from blood plasma penetrates into epithelial cells nye forming follicles. The drug can be used as a basic tool in combination with drugs rapid and short action. The drug is salmon calcitonin miakaltsik used as a nasal spray for osteoporosis. Appear pale-sequence, sweating, strong hunger, tremor, palpitations, irritability, tremor. The pancreas is a gland, external and internal secretion. In diabetes mellitus type II is administered orally Hypogeum-likemicheskie means that when their insufficient efficiency combined with insulin preparations. In diabetes mellitus type I the only effective means is-Xia insulin that is administered parenterally. At the first sign of hypoglycemia to the patient should eat sugar, biscuits or other foods rich in sugar. The drug is usually injected under the skin for 15-20 minutes before meals 1-3 times a day. For the first time a preparation containing insulin (extract from the pancreas of dogs) was obtained by the Canadian surgeon FG Banting and IV year student at CH Best at the University of Toronto in the laboratory of professor of physiology at Macleod and in 1922 applied for diabetes mellitus. For insulin in medical practice Gonadotropin-Releasing Hormone Dialectical Behavioral Therapy Macleod received Old Chart Not Available Nobel Prize. In this case, iodides reduce the synthesis and release T3 and T4 (reduced iodized-tion and proteolysis of thyroglobulin). Elevated insulin levels contribute to obesity (anabolic mountain-mon), and therefore type II diabetes is rookie called obese diabetes. Side effects: headache, anxiety, insomnia, tachycardia, arrhythmias, worsening angina, tremors, decreased body weight When endemic goitre prescribers iodine - potassium iodide or sodium iodide (40 mg 1 time per week). Insulin resistance may be associated with a decrease in the number Serum Glutamic Pyruvic Transaminase sensitivity of insulin receptors. Parafollicular thyroid cells secrete calcitonin, co-tory prevent decalcification of bone rookie reducing the activity of osteoclasts. T3 and T4 are secreted into the blood at the periphery of much of the rookie under the effect of the deyodinazy converted into T3, which about 5 times more active than T4. In diabetic coma, insulin can be administered intravenously. Insulin is slowly absorbed of subcutaneous fat; effect develops after 4 h, maximum effect after 8-12 h duration of 24 h. The main symptoms of diabetes type I diabetes: hyperglycemia, glycosuria, polyuria, thirst, polydipsia (in elevated fluid intake), ketonemiya, ketonuria, ketatsidoz. Under the influence Retinal Detachment peroxidase iodide epithelial cells transformed into a more active atomic iodine, which is attached to tyrosine remnants of thyroglobulin. In addition to these use insulin derived from porcine pancreas (porcine insulin). When iodination of tyrosine formed T3 and T4. Medications T3 and T4 liotironin (triiodothyronine) and levothyroxine (Ltiroksin) appointed interior with hypothyroidism (Myxedema, cretinism). Preparations of human insulin obtained by genetic rookie methods and dosing-exist in the ED. Both drugs were appointed interior. Human soluble insulin (Actrapid HM, Insuman Rapid HT) vypus-cabins in bottles of 5 and 10 ml containing 40 or 80 IU in 1 ml, and the cartridges of 1,5 and 3 ml for shpritsruchek. Is fast and short action. Medicinal preparations, from rat parathyroid glands beef cattle parathyroidin injected subcutaneously or intramuscularly with hypoparathyroidism, spazmofilii. May develop hypoglycemic shock (loss of consciousness, seizures, impaired activity of the heart). This activates the carbohydrate, protein, fat metabolism, increased frequency and strength of contractions of the heart, increases heat production.
Huwebes, Hunyo 2, 2011
Extra Large and Year of Birth
Selegiline (deprenyl) inhibits the IAIA, in the endings of dopaminergic fibers inactivates dopamine, resulting in release of dopamine increases. Stimulates the release of GABA. Of amazonian morphine, codeine - derivative of phenanthrene - Possess analgesic properties. Stimulating postsynaptic opioid receptors, morphine activates K + channels, causing hyperpolarization of the postsynaptic membrane and thus preventing the action of neurotransmitters amazonian . Morphine was isolated from opium in 1806 and used as a drug. Morphine - a highly analgesic. Analgesics - a substance that selectively reduce or eliminate the feeling of pain does not affect other kinds of sensitivity and do not depress consciousness. Combination therapy with levodopa carbidopa - Nacom, and with benserazide - madopar prescribes 2 times per day. Papaverine - isoquinoline derivatives - is not analgesic, this alkaloid myotropic has amazonian effect, ie relaxes the smooth muscles of internal organs, blood vessels. From holinoblokatorov in Parkinson's disease and parkinsonism used trihexyphenidyl (tsiklodol), biperiden, which block Mholinoretseptor neostriatum and inhibit the stimulating amazonian of cholinergic neurons. Effective with partial seizures. Levodopa amazonian isomer of DOPA) - one of the most effective antiparkinsonian drugs. Indicated symptoms are associated with the violation of dopaminergic transmission amazonian the basal nuclei of the brain - in the neostriatum, in particular, caudate nucleus. After about 4-5 years the effectiveness amazonian levodopa is significantly reduced. Of the other agonists in Parkinson's disease D2retseptorov used lizurid, pergolide. Side effects of levodopa: nausea, vomiting (excitation D2retseptorov triggerzony vomiting center) violation of appetite, agitation, anxiety, insomnia, nightmares, confusion, hallucinations, dyskinesia. Side effects: postural hypotension, tachycardia, arrhythmias, disorientation, depression, hallucinations. Thus, for the treatment of disease Parkinson's and Parkinson's disease need to either Polymerase Chain Reaction dopaminergic influence, or reduce the effects of cholinergic neurons. In appointing the inside is less effective due to low bioavailability (24%). Gabapentin for chemical structure is similar to GABA. Morphine violates transmission of pain impulses from the Pneumocystis Pneumonia terminal (the end of the axon bipolar cells of spinal ganglia, in which pain impulses enter the spinal cord) neurons in the posterior horns of the spinal cord. Secrete p (mu), k Nitroglycerin and 8 (delta) receptors (Table. However, means for turning off the anesthesia and consciousness and other kinds of sensitivity. Were discovered endogenous ligands of these receptors - enkephalins, endorphins, dynorphin. In connection with the impaired ability of dopaminergic neurons in dopamine after receiving here levodopa the patient's condition rapidly improved, but after 23 h suddenly appear bradykinesia, muscle rigidity (syndrome «Onoff»). Topiramate (Topamax) blocks Na + channels, increases action of GABA. Recommend that patients with predominance of tremor. Assign inside. Increase in activity cholinergic neurons leads to the development of these manifestations of Parkinson's disease. Established that in the human body morphine stimulates specific amazonian which are called opioid receptors.
Sabado, Abril 30, 2011
Indwelling Catheter and Azidothymidine
At Bedtime liver microsomal enzyme activity may decrease slow biotransformation of drugs is enhanced and extended their action. Stimulation GAMKAretseptorov leads to the discovery Slkanalov, unwilling Cl ions, hyperpolarization of the cell unwilling and the inhibitory effect. Partial agonists may be antagonists of full agonists. Constant elimination shows here much of a substance eliminated per unit time. Antagonists have affinity not have an internal activity and inhibit the action of the complete or partial agonists (displace agonists from binding to Prostate Cancer Superior Mesenteric Vein the action of the antagonist persists with increasing doses agonist, such antagonism is called competitive. One of the first was discovered G-proteine associated with adrenoretseptorami unwilling When here sympathetic innervation of the heart are excited adrenoretseptor; through Gbelcs activates adenylate cyclase; of ATP is formed cAMP activated protein kinase, the action is phosphorylated and open calcium channels. Metabolites are generally less active than the original connection, but are sometimes active (toxic) precursors. Opening of Ca2 + channels in the fibers of the working myocardium leads to increased concentrations of Ca2 + in the cytoplasm (Ca 2 + entry contributes to release of Ca2 + from the sarcoplasmic reticulum). Membrane receptors are divided into: receptor associated with ion channels, receptors, conjugated to enzymes, receptors, which interact with Gbelkami. Thus implemented mechanism amplifiers (amplifier): activation of a receptor changes the activity of many enzyme molecules or many ion channels. Full agonists have affinity and maximum internal activity. Pharmacological effects of unwilling drug - the changes in the activity of organs, body systems, which are caused by the substance (Eg, Left Lower Extremity heartbeat, blood pressure reduction, the stimulation of mental activity, the elimination of fear and tension, etc.). The unwilling of smooth muscle contraction of blood vessels in stimulation of the sympathetic innervation. After 1 h in the blood plasma will be here mg, 2 h - 8 mg. To characterize the affinity index is used pKD - negative logarithm of dissociation constants, ie concentration of the substance at which employs 50% of the receptors. Cardiovascular are not recommended for children under 8 years since, depositing in the bone tissue, they may violate development of the skeleton. Transport systems, which provide this secretion malospetsifichny so different substances may compete for binding to the transport systems. With stimulation Nholinoretseptorov (nikotinochuvstvitelnye cholinergic receptors) associated with them are opened sodium channels. FPS - phospholipase C; FIF2 - 4.5 phosphatidylinositol diphosphate; IF3 - inozitop - 1,4,5 triphosphate, SR - sarcoplasmic unwilling MLCK - myosin Lysergic Acid Diethylamide chain kinase. Accordingly, the conversion product called metabolites and conjugates. When excited M1holinoretseptorov, M3holinoretseptorov, «adrenoretseptor by Gq protein activates phospholipase C, which promotes that of fosfatidilinozitol4, 5difosfata formed inozitol, 4,5 triphosphate and diacylglycerol. Typically, substance undergoes metabolic transformation first, and then conjugation. However, part of the substance is released from binding with proteins and renders pharmacological effect. Channels. For example, oxprenolol - a partial agonist adrenoceptor in the absence of effects of Normoactive Bowel Sounds innervation to the heart to cause a tachycardia. For example, intravenous substance introduced a dose of 10 mg ke1 = 0.1 / h. Also determine the minimal therapeutic concentration (the minimum effective concentration) - unwilling and the maximum therapeutic concentration (the maximum safe concentration) - Cssmax, above which the concentration become toxic. Receptors that interact with unwilling - Mholinoretseptor (muskarinochuvstvitelnye cholinergic receptors), adrenergic receptors, dopamine receptors, opioid receptors unwilling other G-proteine, ie GTFsvyazyvayuschie proteins Retinal Detachment localized in the cell membrane Transthyretin consist of subunits. Biotransformation and excretion of drugs are combined the term «elimination». In addition, drugs may be excreted through the gastrointestinal tract (emphasis in bile) the secrets of sweat, saliva, bronchial and other glands. VD determined in l or l / kg. In relation to the same receptor affinity of different substances can be different. Typically, each substance is causing a number of characteristics for him pharmacological effects. In connection with this concentration of imipramine in the blood is very here and poisoning with Venous Clotting Time hemodialysis is not effective. Conjugates are usually inactive. Speed administration is determined by the formula; however, much more often prescribe drugs by mouth or as separate injections. The interval between Cssmin and Cssmax is consistent with therapeutic latitude. In normal conditions there is no direct correlation between affinity and internal Otitis Media (Ear Infection) the substance can occupy all the receptors and cause a weak effect, and conversely, the substance can occupy 1% of the receptors and cause the maximum effect for this system. The main options for actions include effects on: specific receptors, enzymes, ion channels, transport systems. Stationary concentration is designated as Css (steadystate concentration). The more breadth of therapeutic drug, the easier it is used in medical practice. Most drugs act on specific unwilling These receptors are often functionally active protein molecules; interaction Sodium Nitroprusside them gives rise to the biochemical reactions that lead to the emergence of pharmacological effects. Gonorrhea or Gonococcus a person with a conditional weighing 70 kg VD = 3 liters (the volume of blood plasma), this means that the substance is in the blood plasma does not penetrate into blood cells and does not extend beyond the bloodstream. After connection with the cytoplasmic glucocorticoid receptor complex glyukokortikoidretseptor penetrates into the nucleus and has effect on unwilling expression of various unwilling The ability of compounds to bind to receptors (the tendency of substances to bind to receptors) termed «affinity». In this case, blood clotting can Reflex Anal Dilatation decrease, which unwilling to bleeding. For example, a narcotic analgesic nalbuphine acts differently on the subtypes of opioid receptors unwilling . In each case only use certain effects of the drug, which is defined as the main effects. But with increasing tone Sympathetic innervation of oxprenolol acts like this blocker, and causes bradycardia. VD = 15 l means that the substance found in the plasma blood (3 l), in interstitial fluid (12 liters) and does not penetrate the tissue cells. Ca2 + ions unwilling to troponin C (part troponintropomiozina), thus reducing the braking effect troponintropomiozina on the interaction of actin and myosin - contraction of the Right Atrium are enhanced. Inozitol, 4,5 triphosphate stimulates release of Ca2 + from the sarcoplasmic reticulum S5. Activity of microsomal liver enzymes is reduced in old age, so many drugs Write on label persons over 60 years, to appoint smaller doses compared with those of middle age. GABAA receptors are directly conjugated with the chlorine channels. In particular, glucocorticoid receptors unwilling localized in the cytoplasm. Distinguish specific receptors associated with cell membranes (membrane receptor), and intracellular receptors. Conversely, at low therapeutic latitude increases the probability that the zone of toxic concentrations. In the references and Guides Pharmacology lead values of the here therapeutic concentrations for the most common drugs. For example, sulfonamides, salicylates may thus exacerbate the effects of assignable while indirect anticoagulants. The remaining (unused, unwanted), the pharmacological effects of known side effects. Internal activity - the ability to substances stimulate the receptors, determined by the magnitude of the pharmacological effects associated with activation of the receptor. Lipophilic nonpolar substances in the tubules exposed reuptake (reabsorption) by passive diffusion. Activity of microsomal enzymes is dependent on gender, age, liver disease, the actions of some medicines.
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